rh Activin A protein Active
| Human recombinant protein expressed in Nicotiana benthamiana. |  |
RF0010
Molecular weight: 27.4 kDa disulfide-linked homodimers of two βA chains, each containing 116 amino residues.
Description: Activins are homodimers or heterodimers of the various β subunit isoforms, belonging to the TGFβ family. Mature Activin A has two 116 amino acids residues βA subunits (βA – βA). Activin exhibits a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, hematopoiesis, and reproductive physiology. Activins plays a key role in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells known to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.
Figure 1. Western Blot analysis of recombinant Activin A. Lane MWM: Molecular weight marker (kDa). Lane 1: 200ng of Activin A.
Biological Activity: Activin A is measured by its ability to inhibit mouse plasmacytoma cell line (MPC-11) cells proliferation. ED50 ≤ 5 ng/ml.
Bulk sizes are available upon request.
For R&D purposes only. Purchaser must determine the suitability of the product(s) for their particular use
