rh BMP-7 Active
| Human recombinant protein expressed in Nicotiana benthamiana. |  |
RF0027
Molecular weight: protein composed of 16.5 kDa single chain, containing 144 amino residues.
Description: The bone morphogenetic proteins are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Bone morphogenetic protein 7 (BMP7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFb superfamily member with important functions during embryogenesis, in the adult, and in disease (Chen et al., 2004, Kishigami and Mishina 2005). BMP7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (Sampath et al., 1992, Kazama et al., 2008), inhibits the branching of prostate epithelium (Grishina et al., 2005), and antagonizes epithelialmesenchymal transition (EMT) (Zeisberg et al., 2003, Yu et al., 2009).In pathological conditions, BMP7 inhibits tumor growth and metastasis (Buijs et al., 2007), ameliorates fibrotic damage in nephritis (Zeisberg et al., 2003), and promotes neuroregeneration following brain ischemia (Chou et al., 2006).
Biological Activity: The biological activity of BMP-7 is measured by its ability to induce alkaline phosphatase production by ATDC5 cells. ED50 ≤ 40ng/ml
Figure 1. SDS-PAGE analysis of recombinant BMP-7. Samples were loaded in 15% SDS-polyacrylamide gel and stained with Coomassie blue. Lane 1: Molecular weight marker (kDa); Lane 2 and 3: contains 0.05 ug and 0.3 ug of Agrenvec recombinant BMP-7. Lane 4: immune-detection with specific anti-human BMP-7 by WB
Bulk sizes are available upon request.
For R&D purposes only. Purchaser must determine the suitability of the product(s) for their particular use
